CHDHP Practice Test

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CHDHP Practice Test (V1)

Dive into practice questions

Question 1

According to USP <800>, a pharmacy receives a shipment of hazardous drugs (HDs) from a supplier that are not sealed in plastic. Where must these HDs be unpacked?

  1. In a positive pressure anteroom.
  2. In an area that is under neutral or negative pressure.
  3. At the main pharmacy loading dock, outside the building.
  4. Directly into the automated dispensing cabinet.

Question 2

When administering an injectable antineoplastic hazardous drug, what is the minimum Personal Protective Equipment (PPE) required by USP <800> standards?

  1. One pair of chemotherapy gloves and a facility-provided lab coat.
  2. Two pairs of chemotherapy gloves, an impermeable gown, and a surgical mask.
  3. Two pairs of chemotherapy gloves, a disposable gown tested to resist HD permeability, and eye/face protection.
  4. One pair of sterile gloves and an N95 respirator.

Question 3

What is the primary function of a Containment Primary Engineering Control (C-PEC), such as a Class II Biological Safety Cabinet (BSC), in the context of hazardous drug compounding?

  1. To protect the compounding personnel from exposure to hazardous drug aerosols, spills, and particles.
  2. To maintain the sterility of the final compounded sterile product exclusively.
  3. To ensure the compounding room remains at a positive pressure relative to adjacent areas.
  4. To sterilize the air within the entire hazardous drug buffer room.

Question 4

A vial of a hazardous drug concentrate breaks and spills on the floor of the C-SEC (buffer room). According to best practices and USP <800> guidelines, what is the immediate first step?

  1. Immediately evacuate all personnel from the pharmacy department.
  2. Secure the area of the spill and post warning signs to prevent entry and spread of contamination.
  3. Consult the Safety Data Sheet (SDS) for the specific drug that was spilled.
  4. Begin cleaning the spill using absorbent gauze from the compounding area.

Answer Key

  • Question 1: B. In an area that is under neutral or negative pressure. (USP <800> mandates that HDs must be unpacked in an area with neutral/normal or negative pressure to contain any potential airborne particles or residues from contaminating other areas.)
  • Question 2: C. Two pairs of chemotherapy gloves, a disposable gown tested to resist HD permeability, and eye/face protection. (This combination provides full protection. Two pairs of gloves are required, the gown must be shown to resist HDs, and eye protection is necessary to guard against splashes.)
  • Question 3: A. To protect the compounding personnel from exposure to hazardous drug aerosols, spills, and particles. (The primary purpose of a C-PEC is personnel protection through containment. While it also offers product protection (sterility), its key design feature is to keep hazardous agents safely away from the worker.)
  • Question 4: B. Secure the area of the spill and post warning signs to prevent entry and spread of contamination. (The first priority is to limit exposure. Securing the perimeter of the spill prevents others from walking through it and spreading the contamination while the responsible party gathers the spill kit and dons appropriate PPE.)