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CCPP Certification Program
Module 30: Pharmacogenomics in Disease-State Management
From Genotype to Guideline: Applying PGx Principles in Clinical Practice.
From Knowing the Code to Cracking the Case
In the previous module, you meticulously built your foundational knowledge of pharmacogenomics. You mastered the vocabulary, deconstructed the testing methodologies, and learned to navigate the critical evidence-based resources like CPIC and PharmGKB. You have learned the “what” and the “why” of PGx.
This module is where that foundational knowledge is forged into clinical wisdom. We now pivot from the theoretical to the intensely practical, moving from understanding the principles of PGx to applying them directly in the complex, nuanced context of real-world disease-state management. This is where you learn the “how”—how to take a patient’s diagnosis, their comorbidities, their current medications, and their genetic blueprint, and synthesize it all into a single, authoritative clinical recommendation.
Each section is a deep, case-based dive into a specific therapeutic area. We will move beyond single drug-gene pairs to explore how PGx informs the entire treatment strategy for complex conditions like cardiovascular disease, depression, and cancer. By the end of this module, you will not just be able to interpret a PGx report; you will be able to integrate it seamlessly into the comprehensive management of a patient, solidifying your role as the indispensable medication expert on the collaborative care team.
Your Guide to the Clinical PGx Landscape
This module will equip you with the practical, case-based skills to apply pharmacogenomics across the most impacted areas of modern medicine.
Cardiovascular Pharmacogenomics Case Studies
A deep dive into applying PGx for antiplatelets (clopidogrel), statins (simvastatin), and anticoagulants (warfarin) in complex cardiovascular patients, focusing on high-stakes scenarios like post-PCI care and dyslipidemia management.
Psychiatric Pharmacogenomics Applications
Exploring the use of multi-gene PGx panels to guide antidepressant and antipsychotic selection, moving beyond trial-and-error prescribing for conditions like major depressive disorder and schizophrenia.
Oncology and Chemotherapy Genomic Considerations
A masterclass on critical somatic (tumor) and germline (patient) genetics for chemotherapy agents, focusing on preventing life-threatening toxicities with fluoropyrimidines (DPYD) and thiopurines (TPMT).
Infectious Disease, GI, and Pain-Management Pharmacogenomics
A case-based exploration of PGx in diverse areas, including critical hypersensitivity reactions in HIV (abacavir), hyperuricemia in gout (allopurinol), acid suppression (PPIs), and opioid selection in pain management.
Implementing PGx Services in Collaborative and Cash-Based Models
A practical guide to building and sustaining a clinical PGx service. We will cover developing collaborative practice agreements, creating business models, educating providers, and designing efficient clinical workflows.
